Cancer is a class of diseases in which a cell, or a group of cells display uncontrolled growth, invasion, and sometimes metastasis. It caused about 13% of all human deaths in 2007. In 2015, 9 million are expected to die of cancer. Hence there is tremendous research going on to develop new anticancer drugs. Alkylating agents like sulphur mustard and nitrogen mustards could interfere with cellular proliferation. Hence various benzisoxazole derivatives containing nitrogen mustard were synthesized by various synthetic routes. The structure of the compounds were confirmed by IR, 1H NMR and mass spectral data. Newly synthesized compounds were screened for their In-Vitro Cytotoxic activity and In-Vivo anticancer activity. Out of eight compound synthesized four compounds showed potent cytotoxic activity. These four were screened for In-Vivo anticancer activity out of which one compound showed extremely significant activity at the dose of 40 mg/kg body weight.
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